| Main Title |
Effect of Hexamethyldisiloxane on the Incidence of Chromosome Breaks and Aberrations in Rat Bone Marrow Cells. |
| CORP Author |
Industrial Health Foundation, Inc., Pittsburgh, PA.; Bioassay Systems Corp., Woburn, MA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
8EHQ-86940001601 |
| Stock Number |
OTS0572636 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexamethldisiloxane ;
Toxicity ;
Genotoxicity ;
Chromosomal effects ;
Mammals ;
Rats ;
Parenteral ;
Intraperitoneal ;
CAS No 107-46-0 ;
Hexamethyldisiloxane (CAS No 107-46-0) ;
Toxic substances ;
Laboratory animals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572636 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
43p |
| Abstract |
Hexamethyldisiloxane was tested for its ability to cause chromosomal damage in bone marrow cells in rats. Sprague-Dawley rats were injected intraperitoneally with 1030, 515 and 255 mg/kg of hexamethyldisiloxane. Doses higher than 1030 were not tested since some lethality was observed at 1825 mg/kg. Animals were sacrificed at 6, 24, or 48 hours after injection; cells were removed, processed and examined for chromosomal breaks and/or aberrations. There was no evidence in this study that hexamethyldisiloxane caused chromosomal damage. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Industrial Health Foundation, Inc., Pittsburgh, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028804130 |
| Origin |
NTIS |
| Type |
CAT |
