||Effect of Hexamethyldisiloxane on the Incidence of Chromosome Breaks and Aberrations in Rat Bone Marrow Cells.
||Industrial Health Foundation, Inc., Pittsburgh, PA.; Bioassay Systems Corp., Woburn, MA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Chromosomal effects ;
CAS No 107-46-0 ;
Hexamethyldisiloxane (CAS No 107-46-0) ;
Toxic substances ;
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||Hexamethyldisiloxane was tested for its ability to cause chromosomal damage in bone marrow cells in rats. Sprague-Dawley rats were injected intraperitoneally with 1030, 515 and 255 mg/kg of hexamethyldisiloxane. Doses higher than 1030 were not tested since some lethality was observed at 1825 mg/kg. Animals were sacrificed at 6, 24, or 48 hours after injection; cells were removed, processed and examined for chromosomal breaks and/or aberrations. There was no evidence in this study that hexamethyldisiloxane caused chromosomal damage.
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||57Y; 57U; 68G; 99; 44G
||PC A04/MF A04