||Genetic Evaluation of Extracts of Dow Corning MDF-0107 Foley Catheter Dispersion in the Ames Bacterial Assay, with Cover Letter dated 04/20/1994.
||Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Toxic substances ;
Laboratory animals ;
Gene mutations ;
In vitro ;
CAS No 107-46-0 ;
CAS No 70131-67-8
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The test material was evaluated for genetic activity in a microbial assay (Ames, et al., MUTATION RESEARCH 31:347, 1975) with and without the addition of mammalian metabolic activation. Salmonella typhimurium Str. TA-1535, TA-1537, TA-1538, TA-98, and TA-100 were used as indicator organisms. Dimethy1sulfoxide, absolute ethanol, and sterile physiological saline extracts of the test material prepared by continuous rotary shaking (150 rpm/37C/24 hours) in accordance with the U.S.P. Class VI Plastics Method for biological testing of solid materials, were each introduced into the test system at concentrations of extract ranging from 50 to 3.12pl. A Spot Plate Test against each of the indicator organisms was conducted using the extracts directly on the surface of the agar test plates. No evidence of genetic activity was observed.
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|PUB Date Free Form
||28 Apr 1994
||57Y; 57U; 68G; 99; 44G
||PC A03/MF A03