| Main Title |
Initial Submission: Thirteen-Week Inhalation Exposure of Rats and Dogs to Hexafluoroacetone (HFA) with Cover Letter dated 10/16/1992. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11696 |
| Stock Number |
OTS0571624 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexafluoroacetone ;
Subchronic toxicity ;
Mammals ;
Rats ;
Inhalation ;
Dogs ;
CAS No 13098-39-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571624 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
80p |
| Abstract |
Previous studies have indicated damage to a number of specific organs in rats following exposure to HFA. In order to determine a toxicologically acceptable level for the compound in industrial atmospheres, young, growing, male and female ChR-CD rats and mature, male, beagle dogs were exposed to atmospheres containing 0, 0.1, 1 and 12 parts per million (ppm, v/v ratio) of HFA. The exposures lasted six hours per day, five days per week for thirteen weeks. The suitability of common biochemical and hematological tests as indicators of RFA exposure was also evaluated. At the 12 ppm level, HFA had a significant (p < 0.05) effect on the total body, adrenal, testes, and pituitary weights of rats. There was a tendency toward increased weight of the heart, stomach, liver and lungs as well as lymphocytosis and kidney dysfunction. Histopathologically there was reversible damage to the testes, spleen, thymus, lymph nodes, and bone marrow. Similar effects were onserved in dogs exposed to this same concentration. In both species, the testis was the most susceptible organ. An indication of reversible kidney dysfunction in the rats and increased lung weight in the dogs was observed at the 1 ppm level. There were no gross, biochemical, hematological or histopathologic changes in either species attributable to RFA at the 0.1 ppm exposure level. The average lung weight in dogs exposed to this level, however, was greater than that of the controls. There was no consistent dose-response relationship between average dog-lung weight and HFA concentration. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
27 Oct 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028700770 |
| Origin |
NTIS |
| Type |
CAT |
