| Main Title |
Mutagenicity Evaluation of Hexachlorocyclopentadiene in the Mouse Lymphoma Forward Mutation Assay (final Report) Project Number 20839 (February 1978). |
| CORP Author |
Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-7849061 |
| Stock Number |
OTS0512869 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexachlorocyclopentadiene ;
Genotoxicity ;
Gene Mutations ;
Mammals ;
Mice ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 77-47-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0512869 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
The ability of hexachlorocyclopentadiene to induce specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells (Mouse Lymphoma Forward Mutation Assay) was evaluated in the presence and absence of mouse liver S9 metabolic activation (inducer not reported). Based on preliminary toxicity tests, nonactivated cultures were treated with hexachlorocyclopentadiene at concentrations of 0.0000025, 0.0000050, 0.0000100, 0.0000200, and 0.0000400 ul/ml producing a range of 0.3 - 82.0 % growth relative to the solvent (DMSO) control. Additionally, activated cultures were treated with concentrations of 0.00002, 0.00004, 0.00008, 0.00016, 0.00032, 0.00040, 0.00048, 0.00056, 0.00064, and 0.00125 ul/ml producing growth relative to the solvent control ranging from 2.2 - 115.8%. Hexachlorocyclopentadiene did not induce a positive mutagenic response either with or without metabolic activation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801690 |
| Origin |
NTIS |
| Type |
CAT |
