| Main Title |
Hepatic Porphyria Induced by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in the Mouse. |
| Author |
Goldstein, J. A. ;
Hickman, P. ;
Bergman, H. ;
Vos., J. G. ;
|
| CORP Author |
Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs. |
| Year Published |
1973 |
| Stock Number |
PB-280 843 |
| Additional Subjects |
Herbicides ;
Porphyria ;
Pesticides ;
Toxicology ;
Nitrogen organic compounds ;
Chlorine organic compounds ;
Mice ;
Metabolic diseases ;
Liver ;
Dosage ;
Ingestion(Biology) ;
Bioassay ;
Lethal dosage ;
Tables(Data) ;
Laboratory animals ;
Experimental data ;
Physiological effects ;
Contaminants ;
Pathology ;
Reprints ;
Dioxin/tetrachloro-dibenzo ;
Synthetases/aminolevulinate ;
Porphyrin/carboxy ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-280 843 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Oral administration of 4 weekly doses of 25 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin resulted in induction of delta-aminolevulinic acid synthetase and hepatic porphyria in mice. There was a 2,000-fold increase in the liver content of 8- and 7-carboxyporphyrins. A single lethal oral dose of 150 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin also resulted in a 4,000-fold increase in uroporphyrins in the liver. Doses of tetrachlorofibenzo-p-dioxin which resulted in porphyria also resulted in microscopic evidence of marked liver damage and a moderate increase in the total iron content of the liver. At this time, 2,3,7,8-tetrachlorodibenzo-p-dioxin, a contaminant of a variety of environmenal chemicals, is the most potent porphyrogenic chemical known. |
| Supplementary Notes |
Pub. in Research Communications in Chemical Pathology and Pharmacology, v6 n3 p919-928, Nov 73. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 16, PB-280 830. |
| PUB Date Free Form |
Nov 73 |
| Category Codes |
6T; 57Y; 68E; 68G |
| NTIS Prices |
(Order as PB-280 830, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323741000 |
| Origin |
NTIS |
| Type |
CAT |
