Main Title |
Subacute and Subchronic Oral Toxicity of 1,3-Dichloropropane in the Rat. |
Author |
Terrill, J. B. ;
Robinson, M. ;
Wolfe, G. W. ;
Billups., L. H. ;
|
CORP Author |
Hazleton Labs. America, Inc., Rockville, MD.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA-68-03-4008; EPA/600/J-92/121; |
Stock Number |
PB92-164912 |
Additional Subjects |
Toxicity ;
Kidney ;
Rats ;
Food consumption ;
Body weight ;
Dose-response relationships ;
Hematology ;
Pathology ;
Organ weight ;
Blood chemical analysis ;
Males ;
Females ;
Reprints ;
Dichloropropanes
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-164912 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
1,3-Dichloropropane (DCP) was administered by gavage for 14 and 90 days to male and female Sprague-Dawley-derived rats (10/sex/group). Evaluations included body weight, food consumption, clinical signs, hematology, clinical chemistry, organ weights. and gross and microscopic pathology. In the 14-day study using levels of 200, 600 and 1800 mg/kg/day, all high-dose group animals died while none died in the other two treatment groups. Other signs associated with treatment in high-dose animals included languid behavior, salivation (also seen in mid-dose group animals), dyspnea and prostration. No differences were found between animals in the low or mid-dose groups compared to the control animals for body weight, food consumption, hematology, gross postmortem and histopathology data. Total protein and albumin blood levels were increased for low- and mid-dose females, and mid-dose females, respectively. The clinical chemistry findings appeared to be treatment-related as they were accompanied by significantly increased liver (absolute and relative: both sexes of mid-dose animals) and kidney weights (absolute and relative: mid-dose males). |
Supplementary Notes |
Pub. in Jnl. of the American College of Toxicology, v10 n4 1991. See also PB90-140831. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Subacute and Subchronic Oral Toxicity of 1,3-Dichloropropane in the Rat. |
Category Codes |
57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
216423109 |
Origin |
NTIS |
Type |
CAT |