| Main Title |
Initial Submission: TSCA Health and Safety Study Cover Sheet w/Continuation Sheet re: Results of Rat Pilot Teratology Study with CMC (Confidential), Benzimidazolyl Heterocycle, dated 12/22/1999. (Sanitized). |
| CORP Author |
FMC Corp., Princeton, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1999 |
| Report Number |
8EHQ-1299-14621S |
| Stock Number |
OTS0559868 |
| Additional Subjects |
Toxicology ;
Health effects ;
Rats ;
Teratology ;
Fetuses ;
Females ;
Reproduction(Biology) ;
Body weight ;
Food consumption ;
Hematology ;
Laboratory animals ;
Research and development ;
Gestation ;
Benzimidazolyl heterocycle ;
Carboxymethylcellulose(CMC)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0559868 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
This study is being submitted due to the decreased fetal body weights seen at 5 mg/kg and greater and the increased early resorptions at 10 mg/kg and greater in the absence of maternal toxicity. Groups of eight mated female rats were adminstered (confidential) suspended in 1% carboxymethylcellulose (CMC) on days 6-19 of gestation. It is an experimental still in the R&D pre-commercialization phase. The dose levels were 0, 1.0, 3.0, 5.0, 10 and 30 mg/kg/day. Clinical observations were recorded daily; body weights and food consumption were recorded at three-day intervals. Prior to c-section, blood was collected for hematology determinations. A c-section was performed on each dam. Fetuses were weighed, sexed and examined for external alterations. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
27 Dec 1999 |
| Category Codes |
57Y; 57U; 68G; 99 |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500950 |
| Origin |
NTIS |
| Type |
CAT |
