| Main Title |
Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Carbon Tetrachloride in CD-1 Mice (Journal Version). |
| Author |
Hayes, J. R. ;
Condie, L. W. ;
Borzelleca, J. F. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology. |
| Publisher |
c1986 |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/472; |
| Stock Number |
PB89-104004 |
| Additional Subjects |
Carbon tetrachloride ;
Toxicity ;
Toxic substances ;
Liver ;
Pathology ;
Mortality ;
Laboratory animals ;
Chlorine organic compounds ;
Corn oil ;
Dose-response relationships ;
Hematology ;
Enzymes ;
Liver function tests ;
Body weight ;
Sex factors ;
Organ weight ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-104004 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
CD-1 mice were utilized in 14-day repeated dosing and 90-day subchronic toxicity studies of carbon tetrachloride employing oral gavage with a corn-oil vehicle. The 14-day study used doses of 625, 1250 and 2500 mg/kg and the 90-day subchronic study used doses of 12, 120, 540 and 1200 mg/kg. The 14-day study revealed a dose dependent mortality and decreased body weight in males, whereas females demonstrated mortality only at the high dose. Other major findings were: decreased fibrinogen and lymphocytes, increased LDH, SGPT and SGOT, increased liver weight and decreased lung, thymus and kidney weights. No mortality was evident in the 90-day study. Decreased hemoglobin was evident in males and females and depressed hematocrits in females. LDH, SGPT, SGOT and ALP were increased: blood glucose levels decreased at all dosage levels. Liver and spleen weights were increased at all doses and thymus weights were increased in all but the two lower doses in females. Liver damage was observed at all doses in both sexes. |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v7 n3 p454-463 Oct 86. Prepared in cooperation with Virginia Commonwealth Univ., Richmond. Dept. of Pharmacology and Toxicology. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Carbon Tetrachloride in CD-1 Mice (Journal Version). |
| Category Codes |
57Y; 57U; 44G; 68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
833026576 |
| Origin |
NTIS |
| Type |
CAT |
