| Main Title |
Diethyldithiocarbamate Increases Distribution of Cadmium to Brain but Prevents Cadmium-Induced Neurotoxicity. |
| Author |
O'Callaghan, J. P. ;
Miller, D. B. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/097; |
| Stock Number |
PB86-217460 |
| Additional Subjects |
Cadmium ;
Brain ;
Toxicology ;
Distribution ;
Therapy ;
Reprints ;
Dithiocarbamates ;
Neurotoxicity ;
Heavy metals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-217460 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Dithiocarbamates exhibit potent metal-binding properties which have been exploited in a variety of applications, one of which is chelation therapy for heavy metal toxicity. Such therapy, however, promotes the accumulation of metals in the brain, a side effect which may result in neurotoxicity. To examine this possibility the authors used morphological and biochemical indices to assess the effects of diethyldithiocarbamate (DDC) on cadmium-induced neurotoxicity in the newborn rat. Co-administration of DDC prevented the neurotoxic effects of cadmium while causing a persistent increase in the distribution of cadmium to brain. |
| Supplementary Notes |
Pub. in Brain Research, v370 n2 p354-358 Apr 86. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Diethyldithiocarbamate Increases Distribution of Cadmium to Brain but Prevents Cadmium-Induced Neurotoxicity. |
| PUB Date Free Form |
c1986 |
| Category Codes |
6T; 6O; 57Y; 57Q |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
625516993 |
| Origin |
NTIS |
| Type |
CAT |
