Main Title |
Development of Locomotor Activity of Rat Pups Exposed to Heavy Metals. |
Author |
Ruppert, P. H. ;
Dean, K. F. ;
Reiter, L. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/108; |
Stock Number |
PB85-244481 |
Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Reprints ;
Heavy metals ;
Neurotoxicity ;
Locomotor activity ;
Cadmium ;
Tin/triethyl ;
Tin/trimethyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-244481 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Cadmium (Cd), triethyltin (TET), and trimethyltin (TMT) are heavy metals which are neurotoxic to developing animals. In the present experiment, preweaning assessment of locomotor activity was used to detect and differentiate between the developmental toxicity of these metals. On postnatal day (PND) 5, rat pups received a single injection of either Cd, TET, or TMT. A within-litter design was used for dosing; 1 male and 1 female pup from each litter (N = 10 litters/compound) received either the vehicle, low, medium, or high dosage of the compound. Preweaning motor activity was assessed in 30-min sessions in figure-eight mazes from PND 13 to 21. Motor activity of control animals progressively increased in the initial days of testing, and then both within-session and between-session habituation developed. A single exposure to Cd, TET, and TMT produced hyperactivity by the end of the preweaning period but these metals differed in the day of peak activity, the onset of hyperactivity, and the development of habituation. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 78, n1 p69-77 Mar 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Development of Locomotor Activity of Rat Pups Exposed to Heavy Metals. |
PUB Date Free Form |
1985 |
Category Codes |
6T; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
529826689 |
Origin |
NTIS |
Type |
CAT |