| Main Title |
Role of Beta-Endorphin in the Control of Body Temperature in the Rabbit. |
| Author |
Gordon, C. J. ;
Rezvani, A. H. ;
Heath, J. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Illinois Univ. at Urbana-Champaign. Dept. of Physiology and Biophysics. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/147; |
| Stock Number |
PB85-124477 |
| Additional Subjects |
Thermoregulation ;
Skin temperature ;
Neuron activity ;
Heat loss ;
Rabbits ;
Laboratory animals ;
Metabolism ;
Behavior ;
Reprints ;
Endorphin
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-124477 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
There is evidence of release of the opioid peptide beta-endorphin (beta-E) in the hypothalamus during development of fever and stress-induced hyperthermia. In the unanesthetized rabbit microinjection of beta-E in the preoptic/anterior hypothalamus (POAH) results in peripheral vasoconstriction, inhibition of evaporative heat loss, and a prolonged elevation of body temperature. These reactions are magnified with increases in ambient temperature. Injections of beta-E nearly abolish vasodilation to back heating and also postural enhancement of heat dissipation (sprawling, limb extension) in a hot environment. Beta-E has also been found to reduce the thermal sensitivity of single POAH neurons to ambient heating. However, POAH beta-E injections do not alter metabolic rate at ambient temperatures from 2 to 27 C, and to this extent beta-E-induced hyperthermia is distinct from fever. It is suggested that beta-E reduces sensitivity of POAH neurons to high ambient temperature and that this reduction leads to increased peripheral vasoconstriction, inhibition of evaporative heat loss, and modification of behavioral thermoregulation resulting in a regulated-type elevation in body temperature. A general neural model is proposed to explain the thermoregulatory effects of beta-E in the rabbit. |
| Supplementary Notes |
Prepared in cooperation with Illinois Univ. at Urbana-Champaign. Dept. of Physiology and Biophysics. |
| Availability Notes |
Pub. in Neuroscience and Biobehavioral Reviews, v8 p73-82 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Role of Beta-Endorphin in the Control of Body Temperature in the Rabbit. |
| PUB Date Free Form |
c1984 |
| Category Codes |
6O; 6P; 57Q; 57S |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
504625667 |
| Origin |
NTIS |
| Type |
CAT |
