| Main Title |
Effects of Chlordimeform on Cardiovascular Functional Parameters. Part 2. Acute and Delayed Effects Following Intravenous Administration in the Postweanling Rat. |
| Author |
Watkinson, W. P. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/283; |
| Stock Number |
PB87-179677 |
| Additional Subjects |
Parenteral infusions ;
Toxicity ;
Blood pressure ;
Heart rate ;
Dosage ;
Rats ;
Laboratory animals ;
Pesticides ;
Reprints ;
Chlordimeform
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-179677 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The differential effects of intravenous (IV) intraperitoneal (IP) administration of chlordimeform (CDM) were investigated in 22-30 day old pentobarbital-anesthetized Sprague-Dawley rats. The first group of animals (N=25) were given sequential IV injections of 5, 10, 30, 60, and 120 mg/kg CDM, or normal saline vehicle followed by a single injection of 60 mg/kg CDM. Heart rate (HR), arterial blood pressure (BP), and electrocardiogram (ECG) were monitored for all animals. CDM produced profound acute effects on all cardiovascular parameters monitored and persistent delayed effects on HR and BP. These effects were similar to but less severe than those observed in a previous study using geriatric animals. The second group of animals (N=32) received a single IP injection of either 10, 30, or 60 mg/kg CDM, or normal saline vehicle. The decrease in HR produced by CDM in these animals was comparable to the delayed HR effect seen in the first group despite the differences in dosing regimens and routes of administration. |
| Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health 19, p195-206 1986. See also Part 3, PB87-179685. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Chlordimeform on Cardiovascular Functional Parameters. Part 2. Acute and Delayed Effects Following Intravenous Administration in the Postweanling Rat. |
| PUB Date Free Form |
1986 |
| Category Codes |
68G; 68E; 57Y; 57H |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
716922373 |
| Origin |
NTIS |
| Type |
CAT |
