Main Title |
Effects of Chlordimeform on Cardiovascular Functional Parameters. Part 3. Comparison of Different Routes of Administration in the Postweanling Rat. |
Author |
Watkinson, W. P. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/324; |
Stock Number |
PB87-179685 |
Additional Subjects |
Parenteral infusions ;
Toxicity ;
Blood pressure ;
Heart rate ;
Dosage ;
Rats ;
Laboratory animals ;
Pesticides ;
Reprints ;
Chlordimeform
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-179685 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
The effects of intraperitoneal (IP) administration of chlordimeform (CDM) were investigated in 22-24 day old pentobarbital-anesthetized Sprague-Dawley rats. Animals (N=32) received a single IP injection of either 10, 30, or 60 mg/kg CDM, or normal saline vehicle. Heart rate (HR) and electrocardiogram (ECG) were monitored for all animals, while body temperature was maintained at control levels (37 deg C). HR decreased 21-29% in the treated animals and there were no differences observed across dose groups or over time. ECG effects were confined to rate-related changes only. The decrease in HR produced by CDM in these animals was comparable to the delayed HR effect seen in previous studies from this laboratory (Watkinson, 1985; Watkinson, 1986) despite major differences in dosing regimens and routes of administration. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health 19, p207-217 1986. See also Part 2, PB87-179677. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Chlordimeform on Cardiovascular Functional Parameters. Part 3. Comparison of Different Routes of Administration in the Postweanling Rat. |
PUB Date Free Form |
1986 |
Category Codes |
68G; 68E; 57Y; 57H |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
716922382 |
Origin |
NTIS |
Type |
CAT |