| Main Title |
Initial Submission: 24-Hour Exposure Clonal Syrian Golden Hamster Embryo (SHE) Cell Transformation Assay using Ortho-Toluidine with Cover Letter dated 04/30/1996. |
| CORP Author |
Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1996 |
| Report Number |
8EHQ-0596-13643 |
| Stock Number |
OTS0558517 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Ortho-toluidine ;
Chronic toxicity ;
Cell transformation ;
Mammals ;
Hamsters ;
In vitro ;
CAS No 636-21-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558517 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
49p |
| Abstract |
A 24 hour exposure SHE cell transformation assay was performed to test the morphological transformation potential of ortho-Toluidine. The assay was performed according to the methodology outlined in the attached protocol. In the 24 hour SHE assay ortho-Toluidine gave significant (p<0.05) morphologicd transformation results, relative to the solvent control, at 4 of 5 tested concentrations. The trend test result for this assay was also significantly positive. According to our established criteria which states that either two positive doses or one positive dose and a positive trend test constitutes a positive SHE cell transformation assay result, ortho-Toluidine is considered positive in the 24 hour exposure SHE cell transformation assay. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1 May 1996 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500290 |
| Origin |
NTIS |
| Type |
CAT |
