| Main Title |
In vitro Studies of Chemical Effects on Gap-Junctional Communication: Role of Biotransformation in Toxicant Detection and Use of Assays in Risk Assessment. |
| Author |
Malcolm, A. R. ;
Mills, L. J. ;
Robson, D. L. ;
|
| CORP Author |
Environmental Research Lab., Narragansett, RI. ;Science Applications International Corp., Narragansett, RI. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
ERLN-981 ;EPA/600/J-90/024; |
| Stock Number |
PB90-217670 |
| Additional Subjects |
Toxicity ;
In vivo analysis ;
Reproduction(Biology) ;
In vitro analysis ;
Bioassay ;
Reprints ;
Biotransformation ;
Toxic substances ;
Intercellular junction ;
Risk assessment ;
Chinese hamsters ;
Cyclamates
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-217670 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
A correlation is emerging between the capacity of chemical substances to inhibit gap-junctional intercellular communication in vitro and their capacity to induce reproductive and developmental dysfunction, neurotoxicity and tumor promotion in vivo. A practical issue in identifying chemicals affecting gap-junctional communication in vitro is the role of metabolic products. Phenol, a weak promoter of mouse skin tumors, failed to inhibit gap-junctional communication between Chinese hamster V79 lung fibroblasts; however, five metabolites of phenol suppressed gap-junctional communication in a concentration-related manner. Sodium cyclamate, a possible promoter of bladder cancer in rats, weakly inhibited gap-junctional communication in the same assay; however, three metabolites were stronger inhibitors than sodium cyclamate. Thus, some metabolic products may show activity when parent compounds do not or may show greater activity than parent compounds. |
| Supplementary Notes |
Pub. in In vitro Toxicology, v3p61-67 1990. Prepared in cooperation with Science Applications International Corp., Narragansett, RI. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: In vitro Studies of Chemical Effects on Gap-Junctional Communication: Role of Biotransformation in Toxicant Detection and Use of Assays in Risk Assessment. |
| Category Codes |
57Y; 57I |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019411352 |
| Origin |
NTIS |
| Type |
CAT |
