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RECORD NUMBER: 69 OF 172

Main Title In Vitro Chromosome Aberration Assay with Isobutyraldehyde in V79 Cells, with Cover Letter dated 08/03/1999.
CORP Author BASF Corp., Mount Olive, NJ.; BASF A.G., Ludwigshafen am Rhein (Germany, F.R.). Aktiengesellschaft labor fuer Umweltanalytik und Okologie.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1999
Stock Number OTS0573896
Additional Subjects Toxicology ; Health effects ; Isobutyraldehyde ; Genotoxicity ; Chromosomal effects ; Mammals ; Hamsters ; In vitro ; CAS No 78-84-2
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NTIS  OTS0573896 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 79p
Abstract The aim of the present study was to assess the potential of the test substance isobutyraldehyde or its metabolite(s) to induce structural chromosomal aberrations. For this purpose, an in vitro cytogenetic assay was carried out to determine chromosome aberration frequencies in V79 cells. Most of the substances are not mutagenic or carcinogenic themselves, but only after metabolic transformation, which in vivo is catalyzed mainly by the enzyme systems of the liver. Therefore, the tests are carried out not only directly, but also in the presence of an exogenous metabolic activation system. The most commonly used system is a cofactor- supplemented postmitochondrial fraction (S-9) obtained from livers of rats treated with an enzyme-inducing agent, e.g. Aroclor 1254.
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PUB Date Free Form 9 Aug 1999
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A06/MF A06
Document Type NT
Cataloging Source NTIS/MT
Control Number 028701980
Origin NTIS
Type CAT