Main Title |
Human Carcinogenesis by Arsenic. |
Author |
Mass, M. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-92/316; |
Stock Number |
PB92-227578 |
Additional Subjects |
Carcinogenesis ;
Arsenic ;
Toxicity ;
Cocarcinogenesis ;
Neoplastic cell transformation ;
Risk assessment ;
Mutagenicity tests ;
Syrian hamsters ;
Human ;
Foreign technology
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-227578 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Arsenic is one of the few human carcinogens for which there is not yet a reliable animal cancer model. As such, the classification of arsenic as a carcinogen is based upon data derived from human epidemiologic studies. Although the mechanisms of action of arsenic as a toxic agent have been known for many years, the inability to produce cancer in laboratory animals with arsenic has confounded the operational characterization of arsenic as initiator, promoter, complete carcinogen, or cocarcinogen for humans. Arsenic is clearly a genotoxic agent that induces chromosomal aberrations, micronuclei, and sister chromatid exchange in mammalian cells as well as neoplastically transforms Syrian hamster embryo cells; however, it is not a classical point mutagen. The manuscript reviews some of the scientifically based issues relating to arsenic and risk assessment. (Copyright (c) Science and Technology Letters 1991.) |
Supplementary Notes |
Pub. in Jnl. of Environmental Geochemistry and Health, v14 p49-54 Jul 92. |
NTIS Title Notes |
Journal article. |
Category Codes |
57Y; 57E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
229734160 |
Origin |
NTIS |
Type |
CAT |