Main Title |
Salmonella/mammalian-microsome Plate Incorporation Mutagenicity Assay (Ames Test) & a Chromosome Aberration Assay in Chinese Hamster Ovary Cells with Cover Letter Dated 04/15/1985. |
CORP Author |
Microbiological Associates, Bethesda, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1985 |
Report Number |
40-8584197 |
Stock Number |
OTS0525401 |
Additional Subjects |
Toxicology ;
Health effects ;
9-octadecenylamine ;
Genotoxicity ;
Gene Mutations ;
Bacteria ;
In Vitro ;
Chromosomal Effects ;
Mammals ;
Hamsters ;
Toxic substances ;
Laboratory animals ;
CAS No 112-90-3
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0525401 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
64p |
Abstract |
9-Octadecenylamine (Z) (oleylamine) was assessed for mutagenicity in plate assays with Salmonella typhimurium strains TA1535, TA1537, TA1538, TA100, and TA98 in the presence and absence of Aroclor 1254-induced rat liver homogenate. Tests were conducted at 10 concentrations of test material, ranging from 10 to 10,000 ug/plate. Positive, negative, and solvent (acetone, 50 ug/plate) controls were also tested. No evidence of mutagenic activity was seen at any concentration of test material. A chromosomal aberration assay was conducted with Chinese hamster ovary cells exposed to concentrations of 0.05, 0.15, 0.5, or 1.5 nl/ml of test material in the absence of exogenous metabolic activation, and to concentrations of 0.6, 2, 6, or 20 nl/ml in the presence of Aroclor-induced rat liver homogenate. Under the conditions of these tests, oleylamine did not induce chromosome aberrations in Chinese hamster ovary cells. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
1985 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A05/MF A05 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028802610 |
Origin |
NTIS |
Type |
CAT |