Main Title |
Metabolism of alpha-Naphthoflavone by Rat, Mouse, Rabbit, and Hamster Liver Microsomes. |
Author |
Bergman, H. B. ;
Bryant, B. J. ;
Nesnow, S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA-600/J-84-034; |
Stock Number |
PB84-206150 |
Additional Subjects |
Ribosomes ;
Rats ;
Mice ;
Rabbits ;
Hamsters ;
Reprints ;
Metabolites ;
Naphthoflavone
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-206150 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
The metabolism of alpha-naphthoflavone (ANF) was studied in hepatic microsomes from rats, mice, rabbits, and hamsters, species in which ANF exerts its biological activities. The major metabolites produced by all species were ANF-5,6-oxide, ANF-6-phenol, and ANF-7,8-dihydrodiol. Minor metabolites produced by all species were ANF-5,6-dihydrodiol, ANF-7-phenol, and ANF-9-phenol. In general, the total rates of metabolism were similar within all species: 22-32 nmol ANF metabolized/15 min/mg protein. Mouse liver microsomes were approximately 1.7 to 2.9 times as active as the other species on a nanomole P-450 basis. The major sites of enzymatic oxidation were the 5,6 and 7,8 bonds of ANF where for all species, 94-71% and 15-46% of the total metabolism occurred, respectively. |
Availability Notes |
Pub. in Toxicology and Applied Pharmacology, 72 p469-475 1984. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Metabolism of alpha-Naphthoflavone by Rat, Mouse, Rabbit, and Hamster Liver Microsomes. |
PUB Date Free Form |
c1984 |
Category Codes |
6T; 6O; 57Y; 57Q |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
424418696 |
Origin |
NTIS |
Type |
CAT |