| Main Title |
Letter from Chemical Manufacturers Association to US EPA Submitting a Interim Progress Report on Isopropanol with Attachments. |
| CORP Author |
Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-9022240 |
| Stock Number |
OTS0525975 |
| Additional Subjects |
Toxicology ;
Health effects ;
Isopropanol ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Mice ;
Acute Toxicity ;
Oral ;
Gavage ;
Reproduction/fertility Effects ;
Rabbits ;
Genotoxicity ;
Gene Mutations ;
Hamsters ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 67-63-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525975 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
225p |
| Abstract |
Isopropanol is under evaluation for health effects. Final protocols and amendments for several studies are presented, but results are not provided. Subchronic inhalation toxicity/neurotoxicity tests include a 14-week vapor inhalation study in rats and mice and neurotoxicity evaluation in rats (underway), a 9-day probe vapor inhalation study in rats and mice, and a single exposure vapor inhalation neurotoxicity study in rats (completed). A definitive reproduction and fertility study will be conducted in February, 1990, and developmental toxicity studies in rats and rabbits have been completed. The probe study for the developmental neurotoxicity study is completed, and the definitive study will begin in July, 1990. The gene mutation study in Chinese hamster ovary cells is completed and an in vivo cytogenetics mouse micronucleus study is underway. Oncogenicity studies in rats and mice are scheduled to begin in early 1991. Pharmacokinetics studies in rats (oral, inhalation, and intravenous exposures) are completed, and studies in mice are underway. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A11/MF A11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802690 |
| Origin |
NTIS |
| Type |
CAT |
