||Initial Submission: Basic Toxicity of Methyl Mercaptoacetate with Cover Letter dated 08/26/1992.
||Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Methyl mercaptoacetate ;
Acute toxicity ;
Primary dermal irritation ;
Guinea pigs ;
Subchronic toxicity ;
CAS No 2365-48-2 ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Groups of five male rats were administered 2-11 doses of the test compound by gavage at 10, 100 or 300 mg/kg over 2-15 days. Animals in the high-dose group either died or were euthanatized in poor condition after two doses. Abnormalities observed in the high-dose group included: dehydration; weakness; decreases in white blood cell count and glucose; increases in aspartate aminotransferase, alanine aminotransferase, lactic dehydrogenase, and urea nitrogen; and an increase in relative liver and kidney weights. A variety of gross and histopathologic changes were observed in the moribund animals of the high-dose group. Abnormalities in the mid-dose group were decreased feed intake and minor to moderate eosinophilic cytoplasmic changes in the liver. No treatment related effects were observed in the low-dose group. The test compound has been sold as a pure chemical in volumes of 0-7.5 kg/year; it is not currently sold.
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|PUB Date Free Form
||2 Sep 1992
||57Y; 57U; 68G; 99; 44G
||PC A02/MF A02