| Main Title |
Initial Submission: Basic Toxicity of Chloroacetone with Cover Letter dated 09/01/1992. |
| CORP Author |
Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0992-10564 |
| Stock Number |
OTS0570898 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Chloroacetone ;
Subchronic toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Primary dermal irritation ;
Guinea pigs ;
Dermal ;
Primary dermal sensitization ;
Acute toxicity ;
Inhalation ;
Mice ;
Environmental effects ;
Invertebrates ;
Freshwater fish ;
Mollusks ;
Plants ;
CAS No 78-95-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0570898 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Groups of five male rats were administered three to thirteen doses of the test compound by gavage at 100, 50, or 10 mg/kg over three to seventeen days. The highest dose severely affected feed intake and body weight gain animals in this group died or were euthanatized after four days. Moderate reductions in feed intake and moderate to severe decreases in body weight gain were also observed at the mid- and low-dose levels. Abnormalities observed in the highdose group included necrotizing gastritis, pale livers, and small seminal vesicals. Histopathologic changes in this group included gastric necrosis, alceration, and perforation. Necrosis of tho liver, spleen, adrenal glands and testis appeared secondary to severe gastric irritation and subsequent peritonitis. Moderate to severe conical atrophy of the thymus was also observed at the highdose level. Histopathologic changes in the mid- and low
|
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
4 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018800290 |
| Origin |
NTIS |
| Type |
CAT |
