| Main Title |
N,N Derivatives of p-Phenylenediamine: Single Dose Toxicity and Skin Sensitization with Cover Letter. |
| CORP Author |
American Cyanamid Co., Wayne, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1983 |
| Report Number |
878213644 |
| Stock Number |
OTS-0206438 |
| Additional Subjects |
Toxicity ;
Skin sensitization ;
Lethal doses ;
Rats ;
Injections ;
Guinea pigs ;
Skin irritation ;
Laboratory animals ;
Phenylenediamines
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0206438 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
97p |
| Abstract |
The acute oral LD50 of N,N'-dicyclohexyl g-phenylenedismine for young, male albino rats is 1.07 (0.69-1.66) gm/kg, and that of N,N'-dioctyl g-phenylenedismine is 1.54 (1.06-2.23) gm/kg. The mean LD50 estimates are not significantly different at a level of probability of p = 0.05. Both of the above compounds, as well as N,N'-di-(g-methy1cyclobexyl) E-phenylenediamine were of about the same order of toxicity in single doses by mouth to male albino mice. Similarly, the LD50 estimates by single intraperitoneal injection to mice were comparable for the three products. In a test involving topical application to the depilated skin of male albino guinea pigs, the dicyclobexyl and dioctyl derivatives proved to be only slight primary irritants. However, with repeated application the dicyclohexyl derivative induced a somewhat greater degree of sensitisation than did the diocty1 derivative. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
25 Jul 1983 |
| Category Codes |
57Y |
| NTIS Prices |
PC A06/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019000100 |
| Origin |
NTIS |
| Type |
CAT |
