| Main Title |
Initial Submission: Toxicological Investigation of Polyac, Lot 105 and 161 with Cover Letter dated 10/15/1992. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11582 |
| Stock Number |
OTS0571511 |
| Additional Subjects |
Toxicology ;
Health effects ;
Polyac Lot 105 and 161 ;
Acute toxicity ;
Oral ;
Mammals ;
Rats ;
Gavage ;
Subchronic toxicity ;
Guinea pigs ;
Dermal ;
Primary dermal sensitization ;
Inhalation ;
CAS No 9003-34-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571511 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Six groups of 6 male and 6 female Sprague-Dawley rats per group were each exposed for 4 hours to atmospheres containing aerosolized THERMINOL VP-1 at ambient or heated temperatures. Exposure concentrations ranged from 1.0 to 5.3 mg of THERMINOL VP-1 vapor/aerosol per liter of air. Two additional groups of rats were exposed to house-conditioned air (either ambient or heated) and served as control groups. Exposure was followed by a 14-day observation period and subsequent necropsy. The highest mortality occurred in the 5.3 mg/1 group where 11 out of 12 animals died. No deaths occurred at 1.1 mg/1, data for calculating an LC50 for the females. During exposure observations included salivation, hypoactivity, and active animals. Immediately after exposure, notable observations included labored breathing, red encrustation about the nose and eyes, salivation, wet fur on the ventral side (due to salivation), hypoactivity, and fur coated with test material. Post-exposure observations included red encrustation about eyes and nose and opacity of eyes. By post-exposure Day 14, surviving animals appeared in good health. Decreases in mean body weights were noted in all groups except in the 1.1 mg/1 exposure concentration group and control groups. By post-exposure Day 14, all survivors had=exceeded their pre-exposure weights. Necropsy findings indicated that there were no macroscopic abnormalities which were test material-related. Based on the test results, THERMINOL VP-1 has a combined sex LC50 of 2.66 mg/1 and causes some irritation to sensory organs at concentrations of 1.0 mg/1 or greater. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
27 Oct 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028700240 |
| Origin |
NTIS |
| Type |
CAT |
