| Main Title |
Altered Function and Histology in Guinea Pigs after Inhalation of Diesel Exhaust. |
| Author |
Wiester, M. J. ;
Iltis, R. ;
Moore, W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1980 |
| Report Number |
EPA-600/J-81-030; |
| Stock Number |
PB81-184764 |
| Additional Subjects |
Exhaust emissions ;
Toxicology ;
Air pollution ;
Exhaust gases ;
Guinea pigs ;
Laboratory animals ;
Histology ;
Exposure ;
Reprints ;
Diesel engine exhaust ;
Air pollution effects(Animals) ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB81-184764 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Health effects of inhaled diesel engine exhaust were evaluated in infant guinea pigs following 4 and 8 weeks of exposure. Animals were exposed to 1 part exhaust diluted by 13 parts clean air for 20 hr/day, 7 days/week. Lung function, electrocardiogram, growth rate, and histopathology were assessed following exposure. After 4 weeks, animals exposed to irradiated exhaust, showed a 35% increase in pulmonary air flow resistance, and a small but significant decrease in heart rate. Necropsy, after 8 weeks, showed exhaust exposed animals to have black discoloration of the lungs and increased lung to body weight ratios. Microscopic examination of the lungs from these animals revealed black particulate material in the cytoplasm of alveolar macrophages and in draining lymph nodes. |
| Supplementary Notes |
Pub. in Environmental Research 22, p285-297 1980. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Altered Function and Histology in Guinea Pigs after Inhalation of Diesel Exhaust. |
| PUB Date Free Form |
1980 |
| Category Codes |
6T; 6F; 57Y; 68A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323796077 |
| Origin |
NTIS |
| Type |
CAT |
