Main Title |
Effects of Inhaled Phosgene on Rat Lung Antioxidant Systems. |
Author |
Jaskot, R. H. ;
Grose, E. C. ;
Richards, J. H. ;
Doerfler, D. L. ;
|
CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
1991 |
Year Published |
1991 |
Report Number |
EPA-68-02-4450; EPA/600/J-93/395; |
Stock Number |
PB93-236321 |
Additional Subjects |
Antioxidants ;
Lung ;
Phosgene ;
Air pollution effects(Animals) ;
Glucosephosphate dehydrogenase ;
Rats ;
Glutathione peroxidase ;
Glutathione reductase ;
Superoxide dismutase ;
Dose-response relationships ;
Graphs(Charts) ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-236321 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
A concentration-response and concentration x time (CxT) study were undertaken to determine the effect of phosgene (COCl2) inhalation on pulmonary antioxidant processes as determined by changes in endogenous glutathione (GSH) and antioxidant-associated enzymes (GSH peroxidase, GSH reductase, glucose-6-phosphate dehydrogenase, and superoxide dismutase). Rats were exposed to 0.0, 0.1, 0.25, 0.5, and 1.0 ppm phosgene for 4 hr and 0.25 ppm phosgene for 8 hr. The endpoints were assayed at 0, 1, 2, 3 and 7 days after exposure cessation. The lowest effective concentration was 0.1 ppm phosgene (increases in measured variables from 8 to 35% above control values). At all concentrations, major effects were observed 1 to 2 days after exposure (12 to 159% above control), peaking at 2 to 3 days postexposure (11 to 253% above control), and in some cases were still evident 7 days (10 to 65% above control) after exposure. The CxT study using the same dose (120 ppm-min), but different times and concentration (0.25 ppm for 8 hr and 0.5 ppm for 4 hr), showed a concentration dependence. The peak antioxidant enzyme changes observed for the higher concentration (0.5 ppm) were at least double those observed for the lower concentration (0.25 ppm). (Copyright (c) 1991 Society of Toxicology.) |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v17 n6 p666-674 Nov 91. See also PB86-217478. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Inhaled Phosgene on Rat Lung Antioxidant Systems. |
Category Codes |
57Y; 57F; 68A |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
330925717 |
Origin |
NTIS |
Type |
CAT |