| Main Title |
Comparative In vitro Percutaneous Absorption of p-Substituted Phenols through Rat Skin Using Static and Flow-Through Diffusion Systems. |
| Author |
Hughes, M. F. ;
Shrivastava, S. P. ;
Fisher, H. L. ;
Hall, L. L. ;
|
| CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| Publisher |
cMay 93 |
| Year Published |
1993 |
| Report Number |
EPA-68-02-4450; EPA/600/J-93/416; |
| Stock Number |
PB94-101573 |
| Additional Subjects |
Phenols ;
Skin(Anatomy) ;
Dermal absorption ;
Comparison ;
In vitro analysis ;
Diffusion ;
Rats ;
Graphs(Charts) ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-101573 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The objective of this study was to determine the in vitro percutaneous absorption of (14)C-phenol and eight p-substituted derivatives and to examine the variability of this data. Two diffusion systems, the static and flow-through, were used. Clipped dorsal skin was removed from female F344 rats (90 days old), dermatomed to a thickness of approximately 350 micrometer, placed in a diffusion cell and treated with chemical (4 microgram/sq cm, in ethanol). The cumulative absorption at 72 hr for the phenols in both systems ranged from 15.4 to 97.6%. Greater than 70% of the chemical was absorbed in both systems when the chemical had a log P value between 1.4-3.5. Significant differences in percent absorption between the two diffusion systems were observed with 5 of the compounds. Absorption of acetamidophenol, chlorophenol and cyanophenol were significantly lower in the static system. Absorption of phenol and heptyloxyphenol were significantly lower in the flow-through system. The most variable absorption data in both systems were with the phenols that were absorbed the least (70%). These same chemicals were also on the extremes of the log P scale for the phenols examined. Controlling for the variability of in vitro percutaneous absorption of chemicals is necessary when using the data for human risk assessment. |
| Supplementary Notes |
Pub. in Toxicology In vitro, v7 n3 p221-227 May 93. See also PB90-215898. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparative In vitro Percutaneous Absorption of p-Substituted Phenols through Rat Skin Using Static and Flow-Through Diffusion Systems. |
| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
402522793 |
| Origin |
NTIS |
| Type |
CAT |
