Main Title |
Conditioned Flavor Aversion Induced by Inhaled 'p'-Xylene in Rats. |
Author |
Bushnell, P. J. ;
Peele, D. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/476; |
Stock Number |
PB90-135369 |
Additional Subjects |
Toxicology ;
Xylenes ;
Taste ;
Avoidance learning ;
Conditioned responses ;
Graphs(Charts) ;
Saccharin ;
Reprints ;
Drinking
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-135369 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Xylenes have the potential for widespread public exposure, yet their neurotoxic properties are poorly understood. The conditioned flavor aversion (CFA) paradigm provides a sensitive behavioral assay for the aversiveness of many drugs and toxic chemicals. Male Long-Evans rats were placed on a restricted water schedule (30 min/day) 1 week after arrival in the laboratory at 40 days of age. Ten days later, all rats received 0.2% saccharin in place of water, and then were exposed immediately either to conditioned air or to 50, 100, 200, 400, 800 or 1600 ppm p-xylene for 4 hr, or to 400 ppm p-xylene for 0.5, 1, 2, 4, or 8 hr. The restricted water schedule remained in effect for the next 72 hr, at which time the rats were given a choice between saccharin and water. Inhalation of all concentrations of p-xylene reduced preference for saccharin, with maximal aversion at 800 and 1600 ppm. The aversion produced by p-xylene was maximal at exposures of 2 or more hrs, with shorter exposures producing intermediate effects. Thus inhaled p-xylene at a concentration of 1/2 its TLV (100 ppm) caused a significant, learned change in rats' normal flavor preference for saccharin without disrupting fluid consumption. |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v10 p273-277 1988. Prepared in cooperation with Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Conditioned Flavor Aversion Induced by Inhaled 'p'-Xylene in Rats. |
Category Codes |
57Y; 57T |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
004019190 |
Origin |
NTIS |
Type |
CAT |