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Main Title Effects of Low Dosage of Stable Strontium on Serum Enzymes in Chronic Alcoholics.
Author Stara, J. F. ; Perras, J. ; Pivon, R. J. ; Koch, P. ; Nolan, J. T. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;McGill Univ., Montreal (Quebec). ;La Maison Jean Lapointe, Montreal (Quebec).
Publisher c1986
Year Published 1986
Report Number EPA/600/D-89/032;
Stock Number PB89-223911
Additional Subjects Strontium compounds ; Alcoholism ; Enzymes ; Blood ; Mitochondria ; Dosage ; Glucosephosphate dehydrogenase ; Atomic absorption spectrophotometry ; GGTP
Library Call Number Additional Info Location Last
NTIS  PB89-223911 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20p
Abstract The study shows the systemic effects of low dosage of stable Sr(2+) in relation to chronic ethanol abuse. In the current study, 6 chronic alcoholic patients were administered Sr carbonate (600-700 mg of Sr(2+) per day) for periods of 4-6 weeks, alternating with treatment-free (placebo) intervals. Serum GDH was determined using Koch's modification; GGTP was determined using standard methodology (Gilford Stasar III). Serum ethanol levels were determined using Alcohol Dipstick Methodology of Kapur and Israel. Serum Sr(2+) and Ca(2+) levels were determined by Atomic Absorption Spectrophotometry. In patients receiving Sr(2+), serum GDH levels were decreased 61-68% (range 44.9-88.6%) when compared to the control periods during the acute alcoholic episodes. The effects of Sr(2+) on serum GGTP levels varied in extent of decrease. The preliminary studies indicate that low dosage of Sr(2+) exerts a protective effect on mitochondrial function during acute alcoholic episodes.
Supplementary Notes Pub. in Trace Substances in Environmental Health, v2 p93-109, 1986. Prepared in cooperation with McGill Univ., Montreal (Quebec), and La Maison Jean Lapointe, Montreal (Quebec).
NTIS Title Notes Journal article.
Category Codes 57Q; 57E; 57D
NTIS Prices Not available NTIS
Primary Description 600/22
Document Type NT
Cataloging Source NTIS/MT
Control Number 930020022
Origin NTIS
Type CAT