Main Title |
Assessment of Neurotoxicity: Use of Glial Fibrillary Acidic Protein as a Biomarker. |
Author |
O'Callaghan, J. P. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Publisher |
c1991 |
Year Published |
1991 |
Report Number |
EPA/600/J-91/249; |
Stock Number |
PB92-110527 |
Additional Subjects |
Nervous system ;
Toxicity ;
Biological markers ;
Glial fibrillary acidic protein ;
Astrocytes ;
Radioimmunoassay ;
Toxic substances ;
Hippocampus ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB92-110527 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Diverse neurotoxic insults results in proliferation and hypertrophy of astrocytes. The hallmark of this response is enhanced expression of the major intermediate filament protein of astrocytes, glial fibrillary acidic protein (GFAP). These observations suggest that GFAP may be a useful biomarker of neurotoxicity. To investigate this possibility, the authors administered prototype neurotoxicants to experimental animals and assessed the effects of these agents on the tissue content of GFAP, as determined by radioimmunoassay. A review of the background, design and results of these experiments are presented in the paper. Study findings indicate that radioimmunoassay of GFAP is a sensitive and specific biomarker of neurotoxicity. |
Supplementary Notes |
Pub. in Biomedical and Environmental Sciences, v4 n1-2 p197-206 Jun 91. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Assessment of Neurotoxicity: Use of Glial Fibrillary Acidic Protein as a Biomarker. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
133921372 |
Origin |
NTIS |
Type |
CAT |