Main Title |
Radiation- and Chemically-Induced Chromosome Aberrations in Mouse Oocytes: A Comparison with Effects in Males. |
Author |
Tease, C. ;
|
CORP Author |
Medical Research Council, Chilton (England). Radiobiology Unit.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-93/179 ; OHEA-R-482 |
Stock Number |
PB93-194462 |
Additional Subjects |
Oocytes ;
Chromosome aberrations ;
Biological radiation effects ;
Mutagens ;
Comparison ;
Mice ;
Translocation(Genetics) ;
Males ;
Females ;
Germ cells ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-194462 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Data from studies on radiation-and chemically-induced chromosome aberrations in mouse oocytes have been summarized. An attempt has been made to assess the relative sensitivity to mutagenic agents of female and male germ cells through comparison of observations from mutation studies of female and male mice. No unequivocal evidence of a mutagenic effect limited to a single sex could be found in the cytogenetic data, although differences in relative germ cell sensitivity could be inferred for ionizing radiation and some chemicals. However, the pattern of inter-sex variations was not consistent: for example, irradiation of dictyate oocytes yielded a lower rate of heritable chromosome translocations than the same dose to spermatogonia; in contrast, some chemicals, such as mitomycin C, yielded a larger incidence of chromosome anomalies after treatment of dictyate oocytes than spermatogonia. Overall, the limitations in quality and quantity of cytogenetic data, and the uncertainties associated with comparing information obtained in disparate assays, place severe constraints on the use of observations on induced chromosome aberrations to assess the relative sensitivities of female and male germ cells to environmental mutagens. (Copyright (c) 1992 Elsevier Science Publishers, B.V.) |
Supplementary Notes |
Pub. in Mutation Research Special Issue, 'Female Germ Cells: Biology and Genetic Risk', v296 n1/2 p135-142 Dec 92. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Radiation- and Chemically-Induced Chromosome Aberrations in Mouse Oocytes: A Comparison with Effects in Males. |
Category Codes |
57V; 57Y; 57F |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/21 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
318931983 |
Origin |
NTIS |
Type |
CAT |