| Main Title |
Acute Inhalation of Hexamethylene Diisocyante for a Mouse Micronucleur Assay, with Cover Letter dated 09/30/1998. |
| CORP Author |
Microbiological Associates, Bethesda, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1999 |
| Stock Number |
OTS0573909 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexamethylene diisocyante ;
Geotoxicity ;
Chromosomal effects ;
Mammals ;
Mice ;
Inhalation ;
CAS No 822-06-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0573909 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
183p |
| Abstract |
The test substance, hexamethylene diisocyanate, was tested in the mouse micronucleus assay in collaboration with MPI Research L.L.C. Information on the experimental design and methodology is provided in the attached report provided by MPI Research L.L.C (Appendix III). All in vivo portions of the study, including inhalation exposures were performed by MPI. Animal euthanization, bone marrow collection, slide preparation and evaluation were performed by MA BioServices, Inc. The assay was performed in two phases. The first phase, designed to set exposure levels for the definitive study, consisted ofa preliminary toxicity study (range finding study). The second phase, the micronucleus study, evaluated the potential of the test substance to increase the incidence of micronucleated polychromatic erythrocytes in bone marrow of male and female mice. In both phases of the study, test and control articles were administered by a single 6 hour whole body inhalation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
29 Jan 1999 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A10/MF A10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028702050 |
| Origin |
NTIS |
| Type |
CAT |
