| Main Title |
Status of Monsanto's Phosphate Fiber (Calcium Sodium Metaphosphate) Toxicology Testing Program and EPA Response Letters. |
| CORP Author |
Monsanto Chemical Co., Akron, OH.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
7 Mar 1986 |
| Year Published |
1986 |
| Report Number |
FYI-OTS-0386-0486; |
| Stock Number |
OTS-0000486-0 |
| Additional Subjects |
Carcinogenicity ;
Toxicity ;
Phosphate fibers ;
Rats ;
Laboratory animals ;
Implants ;
Calcium sodium metaphosphate ;
Intrapleural implantation ;
Gelatin pledgets ;
Peural sarcomas ;
Chrysotile asbestos ;
CAS No 23209-59-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000486-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
167p |
| Abstract |
On a For Your Information (FYI) basis, the Monsanto Company submitted information concerning the conduct and preliminary findings from a recently completed intrapleural implantation study of calcium sodium metaphosphate (CAS No. 23209- 59-8) fibers in rats: 'In this test,. . .(calcium sodium metaphosphate) fibers in gelatin pledgets were surgically implanted in the pleural space of experimental rats. Each of 3 groups consisted of approximately 75 males and 75 females at the outset; sub-groups of 5 males and 5 females from each group were sacrificed at 6, 12, and 18 month inter- vals. No (calcium sodium metaphosphate) fiber-induced fibrosarcomas were detected at these interim periods. After the final sacrifice at 24 months, 3 of the 120 (calcium sodium metaphosphate fiber-exposed) animals had fibrosarcomas. Also, at the final sacrifice in the positive control group, in which chrysotile asbestos had been implanted, 5 of 121 animals had fibrosarcomas. In the negative control group, no fibrosarcomas were ob- served.' |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A09/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019100920 |
| Origin |
NTIS |
| Type |
CAT |
