||Status of Monsanto's Phosphate Fiber (Calcium Sodium Metaphosphate) Toxicology Testing Program and EPA Response Letters.
||Monsanto Chemical Co., Akron, OH.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||7 Mar 1986
Phosphate fibers ;
Laboratory animals ;
Calcium sodium metaphosphate ;
Intrapleural implantation ;
Gelatin pledgets ;
Peural sarcomas ;
Chrysotile asbestos ;
CAS No. 23209-59-8
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||On a For Your Information (FYI) basis, the Monsanto Company submitted information concerning the conduct and preliminary findings from a recently completed intrapleural implantation study of calcium sodium metaphosphate (CAS No. 23209- 59-8) fibers in rats: 'In this test,. . .(calcium sodium metaphosphate) fibers in gelatin pledgets were surgically implanted in the pleural space of experimental rats. Each of 3 groups consisted of approximately 75 males and 75 females at the outset; sub-groups of 5 males and 5 females from each group were sacrificed at 6, 12, and 18 month inter- vals. No (calcium sodium metaphosphate) fiber-induced fibrosarcomas were detected at these interim periods. After the final sacrifice at 24 months, 3 of the 120 (calcium sodium metaphosphate fiber-exposed) animals had fibrosarcomas. Also, at the final sacrifice in the positive control group, in which chrysotile asbestos had been implanted, 5 of 121 animals had fibrosarcomas. In the negative control group, no fibrosarcomas were ob- served.'
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