| Main Title |
In vitro Approaches for Determining Mechanisms of Toxicity and Carcinogenicity by Asbestos in the Gastrointestinal and Respiratory Tracts. |
| Author |
Mossman, B. T. ;
|
| CORP Author |
Vermont Univ., Burlington. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-68-03-3130; EPA/600/J-83/261; |
| Stock Number |
PB85-110492 |
| Additional Subjects |
Asbestos ;
Toxicology ;
In vitro analysis ;
Gastrointestinal system ;
Respiratory system ;
Exposure ;
Reprints ;
Carcinogenesis ;
Air pollution effects
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-110492 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Organ and cell cultures of gastrointestinal and tracheobronchial epithelium have been used to document both the interaction of asbestos with mucosal cells and the sequence of cellular events occurring after exposure of cells to fibers. The biological activity of various types of asbestos in vitro is related to surface charge, crystallization and dimensional characteristics. These factors also influence adsorption of natural secretions and serum components to fibers, a process which ameliorates cytotoxicity. Although mechanistic studies at the cellular level are lacking using epithelial cells of the digestive tract, asbestos appears to elicit a constellation of morphologic and biochemical changes in tracheal epithelium that resemble effects of classical tumor promoters on target cells. |
| Availability Notes |
Pub. in Environmental Health Perspectives, v53 p155-161 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: In vitro Approaches for Determining Mechanisms of Toxicity and Carcinogenicity by Asbestos in the Gastrointestinal and Respiratory Tracts. |
| PUB Date Free Form |
c1983 |
| Category Codes |
6T; 6E; 57Y; 57O |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
501824902 |
| Origin |
NTIS |
| Type |
CAT |
