| Main Title |
Studies on the Potent Bacterial Mutagen, 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5'H')-Furanone: Aqueous Stability, XAD Recovery and Analytical Determination in Drinking Water and in Chlorinated Humic Acid Solutions. |
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. ;Cincinnati Univ., OH. Dept. of Chemistry. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/305; |
| Stock Number |
PB88-186796 |
| Additional Subjects |
Mutagens ;
Furans ;
Potable water ;
Water pollution ;
Humic acids ;
Contaminants ;
Water supply ;
Chlorination ;
Salmonella typhimurium ;
Gas chromatography ;
Mass spectroscopy ;
Toxicology ;
Polystyrene ;
Reprints ;
Furanone/chloro-(dichloro-methyl)-hydroxy
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-186796 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was detected by gas chromatography/mass spectrometry in drinking water samples from three locations in the United States, and also in a chlorinated humic acid solution. MX appears to account for a significant proportion of the mutagenicity of these samples, as measured in the Ames test using strain TA100 without metabolic activation. Studies on recovery of MX from spiked water samples by XAD-2/8 resin adsorption/acetone elution indicated that sample acidification prior to resin adsorption was essential to the effective recovery of MX. The stability of MX in aqueous solution was pH- and temperature-dependent. Overall, these results suggest that MX is formed during water chlorination as a result of reaction of chlorine with humic substances, and that a substantial fraction of the MX formed is likely to persist throughout the distribution system. |
| Supplementary Notes |
Pub. in Mutation Research, v189 n4 p363-373 Dec 87. Prepared in cooperation with Cincinnati Univ., OH. Dept. of Chemistry. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Studies on the Potent Bacterial Mutagen, 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5'H')-Furanone: Aqueous Stability, XAD Recovery and Analytical Determination in Drinking Water and in Chlorinated Humic Acid Solutions. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57Y; 68D |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
817620935 |
| Origin |
NTIS |
| Type |
CAT |
