| Main Title |
Usefulness of 'Cyprinodon variegatus' and 'Fundulus grandis' in Carcinogenicity Testing: Advantages and Special Problems. |
| Author |
Courtney, L. A. ;
Couch, J. A. ;
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. |
| Year Published |
1984 |
| Report Number |
EPA-600/J-84-063; |
| Stock Number |
PB84-226513 |
| Additional Subjects |
Toxicology ;
Bioassay ;
Exposure ;
Fishes ;
Reprints ;
Animal models ;
Carcinogenesis ;
Cyprinodon variegatus ;
Fundulus grandis ;
Water pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-226513 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Cyprinodon variegatus and Fundulus grandis, two species of Cyprinodontid fishes extensively studied and used in toxicological and biological investigations, are reviewed and compared as laboratory test animals. Their ecology and general biology, and suitability for various types of experimentation are examined. A laboratory system for exposing critical life stages (e.g., embryos, fry, juveniles) of these species to suspect carcinogens is described. A discussion of the use, findings and potential of these species in oncological studies and carcinogen assays is presented, particularly in regard to responses to three known or suspect carcinogen chemicals (e.g., trifluraline, benzidine, and aflatoxin). Finally, advantages and disadvantages or special problems in using the species as carcinogen test animals are reviewed. |
| Supplementary Notes |
Pub. in National Cancer Institute Monograph, n65 p83-96 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Usefulness of 'Cyprinodon variegatus' and 'Fundulus grandis' in Carcinogenicity Testing: Advantages and Special Problems. |
| PUB Date Free Form |
1984 |
| Category Codes |
6T; 6F; 57Y; 68D |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
431420606 |
| Origin |
NTIS |
| Type |
CAT |
