| Main Title |
DNA Adducts and Induction of Sister Chromatid Exchanges in the Rat Following Benzo(b)-Fluoranthene Administration. |
| Author |
Ross, J. A. ;
Nelson, G. B. ;
Holden, K. L. ;
Kligerman, A. D. ;
Erexson, G. L. ;
|
| CORP Author |
Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Kentucky Univ., Lexington.;Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA-68-02-4456, EPA-R-816185; EPA/600/J-92/438; |
| Stock Number |
PB93-141372 |
| Additional Subjects |
Carcinogenesis ;
Toxicology ;
Aromatic polycyclic hydrocarbons ;
Sister chromatid exchange ;
DNA damage ;
Rats ;
Lymphocytes ;
Lung ;
Liver ;
Reprints ;
Benzo(b)fluoranthene ;
DNA adducts
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-141372 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Benzo(b)fluoranthene (B(b)F) was administered (100 mg/kg by i.p. injection) to male Sprague-Dawley rats. Lungs, livers, and peripheral blood lymphocytes (PBLs) were harvested 1, 3, 5, 7 14, 28, and 56 days after treatment. Several DNA adducts were observed in each tissue, with maximal levels occurring at about 7 days after treatment. Lung DNA exhibited consistently higher adduct levels than liver or PBL DNA. No significant differences were observed between tissues in the types of adducts produced. Sister chromatid exchanges (SCEs) from whole blood cultures were significantly increased relative to concurrent controls between 1 and 14 days after B(b)F administration, with maximum levels at 14 days. |
| Supplementary Notes |
Pub. in Jnl. of Carcinogenesis, v13 n10 p1731-1734 Oct 92. Prepared in cooperation with Kentucky Univ., Lexington. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: DNA Adducts and Induction of Sister Chromatid Exchanges in the Rat Following Benzo(b)-Fluoranthene Administration. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
307031440 |
| Origin |
NTIS |
| Type |
CAT |
