| Main Title |
Support: Letter from BASF to USEPA with Summary of a Life-Cycle Study (F0-F2) on Zebra Fish with Triazole Derivative with Effects on % Survival, Growth, and Reproduction, dated 03/04/2002. |
| CORP Author |
BASF Corp., Mount Olive, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2002 |
| Report Number |
8EHQ-0302-13697 |
| Stock Number |
OTS0558570-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Triazole derivative ;
Zebra fish
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558570-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
A life-cycle study on zebra fish with Triazole Derivative was conducted by the Laboratory for Wildlife- and Fish Toxicology of Experimental Toxicology and Ecology, BASF Aktiengesellschaft, 67056 Ludwigshafen, Germany, for a period of approx. 8 months. The protocol was based on the US- EPA Test Guidelines for the Fish Life-Cycle Toxicity test. The study was performed under flow- through, aerated conditions with 4 concentrations of the test substance and a dilution water control. The test was started with the exposure of approx. 7-month old adult fish (FO-generation), in groups of 10 male plus 10 female fish per replicate and 4 replicates per test concentration or control group. The parent fish were supplied by Zierfisch Center Kickner, Ludwigshafen, Germany. The FO-generation was exposed over approx. 2 months until the eggs for the next generation (F1-generation) were collected, and over an additional time period of approx. 1 month until sacrifice. The number of eggs laid and the fertilization rate was recorded on workdays during a 2-week period starting about 3 weeks after start of exposure. During the rest of the exposure period, the egg numbers were estimated. The Fi-generation was exposed over the whole life cycle. It was started with 4 replicates per concentration or control group with 4 x 50 freshly fertilized eggs each. After 36 days, the number was reduced to a maximum of 25 juveniles per replicate. The observation of egg-laying was started approx. 10 weeks post hatch (start of reproduction). Exact numbers of eggs laid and fertilized eggs were recorded on workdays for a 2-week period starting 13 weeks post hatch. Eggs for the next generation (F2-generation) were collected approx. 20 weeks post hatch of the F1-generation. The Fl- generation was sacrificed approx. 24 weeks post hatch. The F2-generation was exposed from the egg stage until 30 days after the majority of larvae had hatched. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
20 Mar 2002 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500380 |
| Origin |
NTIS |
| Type |
CAT |
