| Main Title |
Initial Submission: Letter from Union Carbide Corporation to USEPA regarding Developmental Toxicity Studies of Propasol Solvent P Vapor in Rats and Rabbits with Cover Letter dated 09/26/1992. |
| CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Union Carbide Corp., Cleveland, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11311 |
| Stock Number |
OTS0571249 |
| Additional Subjects |
Toxicology ;
Health effects ;
Propasol solvent P ;
Reproduction ;
Fertility effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Rabbits ;
CAS No 1569-01-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571249 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
99p |
| Abstract |
Timed-pregnant CD(reg) (Sprague-Dawley) rats were exposed to Propasol(reg) Solvent P vapor for six hours/day on gestational days (gd) 6 through 15. Twenty-five rats per group were exposed to Propasol(reg) Solvent P at target concentrations of 0, 100, 750, or 1500 ppm. The corresponding mean analytical concentrations were 0, 98.4, 755, and 1524 ppm. Maternal clinical signs were taken daily, and body weights were measured on gd 0, 6, 9, 12, 15, 18 and 21. Maternal food and water consumption were measured throughout gestation, gd 0-21. In addition, prior to exposure and immediately following the last exposure day, the eyes of dams were examined by a veterinary ophthalmologist. At scheduled sacrifice on gd 21, maternal body veight, gravid uterine veight and liver weight were measured. Maternal eyes were fixed in neutral buffered formalin for subsequent histological examination. Ovarian corpora lutea of pregnancy were counted and all uterine implantation sites were identified and recorded: resorptions (early or late), dead fetuses and live fetuses. All live fetuses were examined for external malformations (including cleft palate) and variations. Approximately 50% per litter were examined for visceral malformations and variations (including craniofacial alterations) and approximately 50% per litter (intact fetuses) were examined for skeletal malformations and variations. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
5 Oct 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018801930 |
| Origin |
NTIS |
| Type |
CAT |
