| Main Title |
Initial Submission: Evaluation of the Teratogenicity of Inhaled 2,4-pentanedione in Fischer 344 Rats (Final Report) with Cover Letter Dated 10/31/1991. |
| CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1991 |
| Report Number |
88-920000112 |
| Stock Number |
OTS0534562 |
| Additional Subjects |
Toxicology ;
Health effects ;
2 ;
4-pentanedione ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 123-54-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0534562 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
2,4-Pentadione (123-54-6) was evaluated for developmental effects in groups of 25 female Fischer rats administered the test substance by inhalation for 6 hours/day at concentrations of 0, 50, 200, or 400 ppm on days 6 through 15 of gestation. Animals were sacrificed on day 21 of gestation. Animals at 400 ppm showed signs of maternal toxicity (transient reduced body weight and reduced body weight gain during the exposure period). The 200 and 400 ppm groups showed reduced fetal body weights per litter. The incidences of external, visceral, skeletal and total malformations showed no differences from controls. The incidence of visceral variation and partial fetal atelectasis was increased at 400 ppm. Fetuses in this group also showed a consistent pattern of reduced skeletal ossification. The level of significance for all cases was p<0.05. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Union Carbide Corp., Danbury, CT. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1991 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803240 |
| Origin |
NTIS |
| Type |
CAT |
