| Main Title |
Initial Submission: a Three-generation Reproduction Study with Isoxaben in Wistar Rats (Interim Report) with Cover Letter dated 08/21/92. |
| CORP Author |
Lilly (Eli) and Co., Indianapolis, IN.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920006552 |
| Stock Number |
OTS0545151 |
| Additional Subjects |
Toxicology ;
Health effects ;
Isoxaben ;
Reproduction/fertility Effects ;
Combined Teratogenicity/reproductive Effects ;
Mammals ;
Rats ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 82558-50-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0545151 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
469p |
| Abstract |
Isoxaben (82558-50-7) was evaluated for three-generation reproductive toxicity. Twenty-five Wistar rats/sex/group for each parent generation were administered 0, 40, 200, or 1000 mg/kg/day of the test material in the diet. No physical signs of treatment- related toxicity were observed. Food consumption was depressed in F1 females at 1000 mg/kg/day. Significant depressions in body weight gain and body weight were4observed in F1 parental females at 1000 mg/kg/day. Absolute and relative mean liver weights were significantly increased in F0 parental male rats at 1000 mg/kg/day. No treatment-related effects on mating performance or fertility were observed. No treatment-related differences in mean gestation length, mean gestation survival, or live litter size were observed during the first F1 delivery trial. During the second F1 delivery trial, mean live litter size was significantly depressed at 1000 mg/kg/day. Mean body weights of the progeny of dams were significantly depressed at 1000 mg/kg/day. Sex distribution was unaffected by treatment. Increased incidences of exencephaly and microphthalmia were observed at 1000 mg/kg/day. The no-effect level for reproductive toxicity was 200 mg/kg/day. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A21/MF A21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803650 |
| Origin |
NTIS |
| Type |
CAT |
