| Main Title |
Initial Submission: 90-Day Inhalation Toxicity Study of Phenylphosphine in Rats and Dogs with Cover Letter dated 10/15/1992. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-1092-11456 |
| Stock Number |
OTS0571394 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acute toxicity ;
Phenylphosphine ;
Subchronic toxicity ;
Rats ;
Inhalation ;
Dogs ;
Reproduction ;
Fertility effects ;
CAS No 638-21-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571394 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
57p |
| Abstract |
Young adult male and female rats and male beagle dogs were exposed to phenylphosphine for six hours daily, five days per week, for a total of 59 exposures. Two test levels and a control were used. The test levels were designed as 0.3 and 3.0 ppa (viv), but averaged 0.6 and 2.2 ppm over the 90-day period. At 0.6 ppm, mild clinical and hem:tologic effects were observed in some anamals; however, histopathologic examination of tissues revealed no test compound-related effects. Rats exposed to the 2.2 ppm level showed severe clinical, hematological, and histopathologic effects. Dogs exposed at this level vere more affected than those at the lower level; however, they were less severely affected than rats exposed to 0.6 ppm. Testicular degeneration observed in rats at the high level was irreversible, while in dogs it showed a slight reversal. Two and 1/S parts per million (2.2 ppm) phenylphosphine is a definite chronic affect level based on data collected during this study, while 0.6 ppm appears to be a threshold level for effect. The possibility of species differences must always be considered and a more susceptible species may be affected at a lower dose level dban the rats were in this experiment. It follow chat all results cannot be extrapolated to humans, a species for which no phenylphosphine exposure data are available. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
27 Oct 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018802480 |
| Origin |
NTIS |
| Type |
CAT |
