Main Title |
Initial Submission: 2-propenoic Acid, Butyl Ester: Translation of German Article on Industrial Hygiene and Toxicology Describing Studies in Rats with Cover Letter dated 08/12/92. |
CORP Author |
BASF Corp., Mount Olive, NJ.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1992 |
Report Number |
88-920005597 |
Stock Number |
OTS0544381 |
Additional Subjects |
Toxicology ;
Health effects ;
Butyl Ester ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 141-32-2
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0544381 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
29p |
Abstract |
N-butyl acrylate (CAS No. 141-32-3) was evaluated for developmental toxicity. It was administered to groups of 15 fertilized female rats per group dosed with 0, 25, 135, and 250 ppm for 6 hours per day by inhalation on days 6-15 of gestation. Body weight gain was reduced by 95% at 135 ppm or above. There were no deaths in any of the test groups. Conception rate, corpora lutea, or weight of placentas were not affected by treatment. The percent of live implants per pregnant rat were reduced by 95% relative to controls. The number of dead implants per pregnant rat was increased in comparison to controls (significance 99%). The number of early resorptions increased at 135 ppm or above (statistical significance was not reported). Medium-late resorptions were increased in all test groups (statistical significance was not reported). No late resorptions were observed in any of the test groups. The percentage of dead implants per pregnant rat was increased by 99% relative to controls. The weight of male fetuses was increased by 95% relative to controls. The weight of female fetuses was not altered by treatment. The length of the fetuses was larger on the average by 99% at 25 ppm or above. Anomalies, variations and/or retardations observed in treatment groups were not different from controls. It was concluded that the toxic dose was between 25 and 135 ppm. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Rohm and Haas Co., Philadelphia, PA. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
1992 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028803590 |
Origin |
NTIS |
Type |
CAT |