| Main Title |
Effect of 2-chlorotoluene Vapour on Pregnancy of the Rat with Cover Letter dated 08/31/1983. |
| CORP Author |
Huntingdon Research Center, New City, NY.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1983 |
| Report Number |
40-8335095 |
| Stock Number |
OTS0507458 |
| Additional Subjects |
Toxicology ;
Health effects ;
2-chlorotoluene ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Subchronic Toxicity ;
Toxic substances ;
Laboratory animals ;
CAS No 95-49-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0507458 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
87p |
| Abstract |
2-Chlorotoluene was tested for developmental toxicity in groups of 25 bred Charles River CD rats receiving whole body exposure to nominal vapor concentrations of 0, 1, 3, and 9 mg/L, for 6 hours/day on days 6-19 inclusive of gestation. At 9 mg/L, all parent animals showed brown fur staining and slight to moderate ataxia, and some showed lacrimation and/or salivation during exposure. Food consumption and mean body weight gain were significantly reduced at 9 mg/L. At 9 mg/L, litter and fetal weight were significantly reduced. There was no significant effect upon litter size, or pre- or post implantation loss. In the high-dose group, skeletal ossification was reduced, providing an increased incidence of fetuses with sternal variants and contributing to a significant increase in fetuses with skeletal anomalies; the authors implied that these effects were directly related to the lower fetal weights observed in the high- dose group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Occidental Chemical Corp., Grand Island, NY. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1983 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801210 |
| Origin |
NTIS |
| Type |
CAT |
