| Main Title |
Teratology Study in Rats with Test Article Acetone Cyanohydrin with Cover Letter dated 04/25/1986. |
| CORP Author |
International Research and Development Corp., Mattawan, MI.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
878216401 |
| Stock Number |
OTS0510329 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acetone Cyanohydrin (75-86-5) ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 75-86-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510329 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
89p |
| Abstract |
Teratogenicity was evaluated in groups of pregnant Charles River COBS CD rats (25/group) given acetone cyanohydrin via gavage at doses of 0, 1, 3 or 10mg/kg/day on days 6 through 15 of gestation. There was no effect of treatment for all animals as indicated by mortality, antemortem and necropsy observations. A slight reduction in body weight gain was noted for mid- and high- dose animals. Statistically significant differences between high dose group and controls (vehicle, deionized water) were observed for the number of corpora lutea/dam and number of implantations/dam. The viable fetuses/dam, postimplanation losses/dam, mean fetalbody weight and fetal sex distribution in the high dose group and all values for the low- and mid- dose groups were comparable to the controls. The incidence of fetal malformations and developmental variations for all fetuses of treated animals were comparable to the control group fetuses. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Monsanto Chemical Co., Dayton, OH. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801470 |
| Origin |
NTIS |
| Type |
CAT |
