| Main Title |
Teratogenic Potential of Dow Corning Antifoam A Compound, Food Grade in Rabbits, with Cover Letter dated 04/20/1994. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
OTS-86940001433 |
| Stock Number |
OTS0558163 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Siloxanes ;
Silicones ;
Di-Me ;
Reproduction ;
Fertility effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Oral ;
Diet ;
CAS No 63148-62-9 ;
CAS No 67762-90-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558163 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
43p |
| Abstract |
The teratogenic potential of DOW CORNING Antifoam A Compound, Food Grade (hereafter referred to as DOW CORNING Antifoam A Compound) administered in the diet was studied in rabbits. Pregnant New Zealand white rabbits were given food grade DOW CORNING Antifoam A Compound in the diet at concen- trations of 0, 0.5, 1.0, and 2.5% from the morning of day 6 through the morning of day 19 of gestation. There were no overt signs of toxicity in the dams, and no statistically significant differences in feed consumption at any level compared to the control group. There was no evidence of adverse effects in mean maternal body weight or liver weight of the treated females. The incidence of resorptions among the total fetal population was not altered by feeding DOW CORNING Antifoam A Compound to pregnant rabbits at the three dictary levels. Term fetuses were examined by standard teratological techniques. Male and female pup weights were unaffected by the maternal treatment. DOW CORNING Antifoam A Compound had no statistically significant adverse effects on the incidence of external, visceral or skeletal abnormalities. On the basis of those results, it is concluded that DOW CORNING Antifoam A Compound is not embryotoxic or teratogenic in rabbits at dietary levels up to 2.5%. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
28 Apr 1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500860 |
| Origin |
NTIS |
| Type |
CAT |
