| Main Title |
2-phenoxyethanol: Dermal Teratology Probe Study in Rabbits with Cover Letter. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
878214896 |
| Stock Number |
OTS0206692 |
| Additional Subjects |
Toxicology ;
Health effects ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 122-99-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0206692 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
19p |
| Abstract |
A dermal teratology study was conducted in groups of 10 mated New Zealand White rabbits administered occluded doses undiluted 2-phenoxyethanol at dose levels of 0, 300, 600, 1000 mg/kg/day on gestation days (GD) 6-18. Mortality was observed (number not reported). Maternal toxicity was indicated in the highest dose group by a significant weight loss on GD 15-18 (Bartlett's test for Variance). Gross necropsy in does which died or were sacrificed revealed hemoglobinuria, pale livers, dark kidneys and dark urine in the bladder characteristic of the breakdown of red blood cells. One doe in the 600 mg/kg/day dose group was found to have an intussuception of the colon, while another had severe dermal irritation which appeared normal by GD 11. No evidence of embryonal toxicity was observed in rabbits in any treatment group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1984 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801040 |
| Origin |
NTIS |
| Type |
CAT |
