| Main Title |
Single Generation Reproduction and Embryotoxicity Study with Isopropyl Alcohol in Rats (Final Report) with Attachments and Cover Letter Dated 01/30/1992. |
| CORP Author |
British Industrial Biological Research Association, Carshalton (England).; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
86-920000729 |
| Stock Number |
OTS0535608 |
| Additional Subjects |
Toxicology ;
Health effects ;
Isopropanol (67-63-0) ;
Reproduction/fertility Effects ;
Mammals ;
Rats ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 67-63-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0535608 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
168p |
| Abstract |
Isopropanol (CAS No. 67-63-0) was tested for reproductive toxicity. The test substance was administered orally in the drinking water at 0, 0.5, 1.0, and 2.0% to male (10/group) and female (30/group) rats. The females were treated for 21 days before mating and continued receiving treatment throughout the study. After a 70-day treatment period, each male was paired with three females at the same treatment level; of the three females, one was sacrificed on day 19 of gestation and the two were allowed to litter. As compared to controls, at 2.0%, decreases in food and water intake and body weight, and increases in kidney and liver weights were noted in both sexes, and there were decreases in pup weight gain and survival. The fetuses of the sacrificed females in the highest group had whole body edema and slightly reduced body weight as compared to controls. The surviving pups had dose-related increases in relative liver weights. The NOEL for reproductive effects was 1.0%. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A09/MF A09 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803420 |
| Origin |
NTIS |
| Type |
CAT |
