| Main Title |
Developmental Toxicity Study of Inhaled Methyl Tertiary Butyl Ether in New Zealand White Rabbits (Final Report) with Attachments and Cover Letter Dated 07/12/1989. |
| CORP Author |
Bushy Run Research Ctr; Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8913426 |
| Stock Number |
OTS0528041 |
| Additional Subjects |
Toxicology ;
Health effects ;
Methyl-t-butyl Ether ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 1634-04-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0528041 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
280p |
| Abstract |
Methyl tertiary butyl ether was evaluated for developmental toxicity in groups of 15 bred female New Zealand white rabbits receiving whole-body exposure to nominal vapor concentrations of 0, 100, 4000, and 8000 ppm for 6 hours/day on days 6-18 of gestation. Maternal mortality was not observed and all does were sacrificed on gestation day 29. A statistically significant (p < 0.01) reduction in food consumption rates was observed at 8000 ppm. Gross necropsy revealed significantly (p < 0.05) increased liver weights at 8000 ppm. There were no differences between control and treatment groups with respect to the number of corpora lutea, early and late resorptions, non-viable fetuses, viable implantations, pre- or post-implantation losses, sex ratios, or fetal malformations (skeletal, external, or visceral). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A14/MF A14 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803010 |
| Origin |
NTIS |
| Type |
CAT |
